Combined fructose and sucrose consumption from an early age aggravates cardiac oxidative damage and causes a dilated cardiomyopathy in SHR rats

Obesity increases the risk of arterial hypertension in young adults and favors an early-onset cardiomyopathy by generating oxidative stress. In this sense, indiscriminate consumption sucrose fructose sweetened beverages from early ages causes obesity, however its consequences on heart when there is a genetic predisposition to develop are not clear. We compared effects sucrose, fructose, their combination weanling male spontaneously hypertensive rats determine relationship between hypertension, these sugars degree cardiac hypertrophy, stress Ca2+/calmodulin dependent protein kinase II delta oxidation. Histological, biochemical, western blot studies were performed 12 weeks after treatment initiation. found that chronic or leads exacerbates hypertension-induced metabolic alterations, stress, oxidation hypertrophy. Nonetheless, consumed together, alterations worsen accompanied dilated cardiomyopathy. These data suggest combined starting maternal weaning with accelerates progression resulting